Tarducci was born in Senigallia, Marche. He became interested in music from a young age; he wrote and performed his first piece when he was 17 years old.
In 1995 he recorded his first demo.
Following his underground success, Fabri Fibra began performing around Italy. In 2000 he established his label and group Teste Mobili Records (Bobbing Head Records), and collaborated with various Italian rap groups, lending vocals as well as lyrics to the mixtape circuit.